We evaluate the conflict processing and response of inhibition with the Stroop task in patients with intractable temporal lobe epilepsy who underwent depth electrode amygdala-hippocampal recording to determine focus laterality for further lobectomy and control subjects analyzing the cerebral metabolic response by fMRI. Patients showed longer reaction times and more errors in the Stroop task than control subjects. At the conflict processing and response of inhibition, TLE patients presented difficulties in the executive system regulated by the frontal lobe; they showed dominant brain activation in the right hemisphere frontal lobe and right inferior frontal junction, inferior frontal, superior frontal, middle frontal gyri and ACC. Patients did not show left activation, as observed in control subjects. Temporal Lobe Epilepsy (TLE) was defined in 1989 by the ILAE as a syndrome characterized by recurrent, unprovoked crises that originate in the medial or lateral portion of the temporal lobe. Нis is the most frequent type of focal epilepsy, and it is considered a medical and social problem, since 30% of such patients are drug-resistant to treatment. Нerefore, epilepsy has been considered a public health problem, for there are approximately 50 million patients whose quality of life has been Detٴected; OMS studies have demonstrated that epilepsy can cause alterations in the cerebral functioning of patients who have a high risk of presenting cognitive deterioration and behavioral abnormalities that can compromise their personal, academic, work and social development