Epilepsy is an abnormality in the central nervous system which characterized in recurrent or unprovoked seizures. Nurse care is one of the important specialists for management of the patients. The aims of this study was evaluating role of nurse care on management of patients with epilepsy. This study is a brief review to evaluate role of nurses in management of patients with epilepsy. Nurses should improve the quality of patient care: 1- We need to have a plan for increasing the knowledge of ESNS, 2- Government should make a new course in Faculty of Nursing and Midwifery, 3- Develop guide lines for ESNS and prepare appropriate programs. Epilepsy is an abnormality in CNS that characterized by recurrent seizures due to abnormal, excessive or synchronous neuronal activity in the brain. Epilepsy can be best understood as a group of syndromes with vastly divergent symptoms all involving episodic abnormal electrical activity in the brain. Nurse care in Epilepsy is useful in assessing symptoms, diagnosis, tests and risk management. Epilepsy Nurses are a part of professional care system which has a man role to manage and evaluate of patients with complex uncontrolled Epilepsy. Нese nurses can manage diagnosing and changing antiepileptic drug of patents. So epilepsy nurses have mainly eوٴect with highly useful. Same studies, evaluated eوٴect of nurses on patients with epilepsy that demonstrated epilepsy monitoring with Acute Care Nurse Practitioner (ACNP) can eوٴect on patient outcomes, staying in the hospital, costs, decreasing the number of laboratory test and satisfaction of patients. So epilepsy patients need to chronic treatment by primary care that this care included an epilepsy neurologist and epilepsy nurses. Нe roles of Epilepsy nurses is included dissemination of performing Epilepsy Audit towards creation of a proÙ½Oe of Epilepsy, accurate information to the clients to care better and improving treatment plans and goals. Нe role of epilepsy special nurse (ESN) has developed signiÙ½cDntO\ over the past twenty years. We are delighted to be able to reply our work. One of the testing of EEG is video EEG monitoring which records video and brain waves in seizures. Also it’s a helpful device to determine type of seizure and following select a suitable treatment by doctor. Нe patients need Video EEG Monitoring least 4 to 6 days in hospital. Also the stay of patients maybe takes more than 6 days. Нe episodic events may diagnose by video EEG monitoring but these episode events don’t occur in fainting or black-out spells, epileptic seizures, events of unknown origin, hallucinations, confusion or behavioral challenges. In this monitoring, patients stay in room by video EEG, also the epilepsy nurse support patients in the all of the times. Нe epilepsy monitoring unit (EMU) rooms have private bathroom and a pull out couch. Нe beds have two padded side rails for safety of patients because the risk of falling in these patients is high and nurse must ensure of safety of bed. In the monitoring of patients with epilepsy, the nurses don’t use cigarette or smoking or mobile.